Beta Testing

Azelaic Acid

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Potential Risk IndexTM:


About:

Functions :
1. Flavor / Flavoring / Flavor Enhancer – Provides or enhances a particular taste or smell
2. Skin Whitening Agent – Reduces the melanin content of the skin

Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale ), a yeast that lives on normal skin. It is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Azelaic acid ‘s antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis. Azelaic Acid is a naturally occurring dicarboxylic acid produced by Malassezia furfur and found in whole grain cereals, rye, barley and animal products. Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins. Azelaic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers. Azelaic acid also possesses a direct anti-inflammatory effect due to its scavenger activity of free oxygen radical. This drug is used topically to reduce inflammation associated with acne and rosacea.

Scientific References :
1. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/2266


Safety and Hazards (UN GHS):

1. Causes skin irritation (H315)
2. Causes serious eye irritation (H319)
3. May cause respiratory irritation (H335)

Potential Health Benefits For:

1. Acne Vulgaris ( PubMed ID:17456913 )
2. Atherosclerosis ( PubMed ID:19880116 )
3. Dermatitis, Atopic ( PubMed ID:19804495 )
4. Dermatitis, Perioral ( PubMed ID:19804495 )
5. Hutchinson's Melanotic Freckle ( PubMed ID:8635147 )
6. Hyperpigmentation ( PubMed ID:20804622 )
7. Inflammation ( PubMed ID:18803456 )
8. Melanosis ( PubMed ID:22151936 )
9. Psoriasis ( PubMed ID:20684146 )
10. Rosacea ( PubMed ID:17472690 )
11. Skin Diseases ( PubMed ID:20025951 )
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