Beta Testing

Carnitine

Share on facebook
Share on twitter
Share on email

Potential Risk IndexTM:


About:

Levocarnitine is a carrier molecule in the transport of long chain fatty acids across the inner mitochondrial membrane. It also exports acyl groups from subcellular organelles and from cells to urine before they accumulate to toxic concentrations. Lack of carnitine can lead to liver, heart, and muscle problems. Carnitine deficiency is defined biochemically as abnormally low plasma concentrations of free carnitine , less than 20 µmol/L at one week post term and may be associated with low tissue and/or urine concentrations. Further, this condition may be associated with a plasma concentration ratio of acylcarnitine/ levocarnitine greater than 0.4 or abnormally elevated concentrations of acylcarnitine in the urine. Only the L isomer of carnitine (sometimes called vitamin BT ) affects lipid metabolism. The ” vitamin BT ” form actually contains D,L-carnitine , which competitively inhibits levocarnitine and can cause deficiency. Levocarnitine can be used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias. Levocarnitine is an amino acid derivative. Levocarnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy production. Fatty acids are utilized as an energy substrate in all tissues except the brain. (NCI04)

Scientific References :
1. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/10917


Safety and Hazards (UN GHS):

1. Causes skin irritation (H315)
2. Causes serious eye irritation (H319)

Potential Health Concerns For:

1. Arthritis, Experimental ( PubMed ID:24709313 )
2. Cardiomyopathy, Dilated ( PubMed ID:16040888 )
3. Chemical and Drug Induced Liver Injury ( PubMed ID:18597074 )
4. Kidney Diseases ( PubMed ID:18852009 )
5. Mitochondrial Myopathies ( PubMed ID:7944307 )
6. Muscular Diseases ( PubMed ID:1494519 )

Potential Health Benefits For:

1. Acute Kidney Injury ( PubMed ID:16897003 )
2. Cardiomegaly ( PubMed ID:26581635 )
3. Cardiomyopathies ( PubMed ID:3945174 )
4. Cardiotoxicity ( PubMed ID:29800642 )
5. Chromosome Breakage ( PubMed ID:28396261 )
6. Drug Overdose ( PubMed ID:8681902 )
7. Drug-Related Side Effects and Adverse Reactions ( PubMed ID:18852009 )
8. Fanconi Syndrome ( PubMed ID:23213347 )
9. Fibrosis ( PubMed ID:26581635 )
10. Hearing Disorders ( PubMed ID:16239342 )
11. Heart Diseases ( PubMed ID:16423284 )
12. Hepatic Encephalopathy ( PubMed ID:15935684 )
13. Hyperammonemia ( PubMed ID:15935684 )
14. Hyperlipidemias ( PubMed ID:30256492 )
15. Hypertension ( PubMed ID:26581635 )
16. Insulin Resistance ( PubMed ID:30256492 )
17. Liver Cirrhosis, Experimental ( PubMed ID:14748882 )
18. Liver Failure, Acute ( PubMed ID:10801061 )
19. Liver Neoplasms ( PubMed ID:19294768 )
20. Lymphoma, Non-Hodgkin ( PubMed ID:16283381 )
21. Metabolic Syndrome X ( PubMed ID:30256492 )
22. Mitochondrial Diseases ( PubMed ID:12408365 )
23. Myocardial Infarction ( PubMed ID:3964138 )
24. Myocardial Reperfusion Injury ( PubMed ID:29186614 )
25. Peripheral Nervous System Diseases ( PubMed ID:20216233 )
26. Prenatal Exposure Delayed Effects ( PubMed ID:29800642 )
27. Prenatal Injuries ( PubMed ID:16239342 )
28. Reye Syndrome ( PubMed ID:28452736 )
29. Right ventricle hypoplasia ( PubMed ID:29800642 )
30. Weight Gain ( PubMed ID:30256492 )
Share on facebook
Share on twitter
Share on email

Leave a Comment