Beta Testing

Creatine

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Potential Risk IndexTM:


About:

Functions :
1. Dietary / Nutritional Supplement – Vitamins, minerals, proteins, fatty acids or probiotics which is eaten to improve nutritional intake

Creatine is a essential, non-proteinaceous amino acid found in all animals and, in some plants. Creatine is synthesized in the kidney, liver and pancreas from L-arginine , glycine and L-methionine . Following its biosynthesis, creatine is transported to the skeletal muscle, heart, brain and other tissues. Most of the creatine is metabolized in these tissues to phosphocreatine ( creatine phosphate ). Phosphocreatine is a major energy storage form in the body. Supplemental creatine may have an energy-generating action during anaerobic exercise and may also have neuroprotective and cardioprotective actions. Creatine is an endogenous amino acid derivative produced by vertebrate animals and occurring primarily in muscle cells. Creatine is important for energy storage; it is phosphorylated to creatine phosphate , which serves as a phosphate donor in the conversion of ADP to ATP and supplies energy necessary for muscle contraction. Dietary supplementation with creatine may improve muscle wasting associated with cancer and other chronic diseases.

Scientific References :
1. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/586


Safety and Hazards (UN GHS):

1. Causes skin irritation (H315)
2. Causes serious eye irritation (H319)
3. May cause respiratory irritation (H335)

Potential Health Concerns For:

1. Acidosis, Lactic ( PubMed ID:20223410 )
2. Acute Kidney Injury ( PubMed ID:12394880 )
3. Arthritis, Experimental ( PubMed ID:24709313 )
4. Atrial Fibrillation ( PubMed ID:15899738 )
5. Autistic Disorder ( PubMed ID:16818868 )
6. Bipolar Disorder ( PubMed ID:17988366 )
7. Chemical and Drug Induced Liver Injury ( PubMed ID:18452122 )
8. Cholestasis ( PubMed ID:18452122 )
9. Cocaine-Related Disorders ( PubMed ID:19906515 )
10. Compartment Syndromes ( PubMed ID:10764196 )
11. Creatine deficiency, X-linked ( PubMed ID:12210795 )
12. Dehydration ( PubMed ID:10075534 )
13. Depressive Disorder ( PubMed ID:9018096 )
14. Diarrhea ( PubMed ID:11740307 )
16. Glomerulonephritis, Membranoproliferative ( PubMed ID:14725210 )
17. Heat Stroke ( PubMed ID:12182766 )
18. Jaundice ( PubMed ID:18452122 )
19. Kidney Diseases ( PubMed ID:20061359 )
20. Muscle Cramp ( PubMed ID:11740307 )
22. Nephritis, Interstitial ( PubMed ID:10075534 )
24. Postoperative Complications ( PubMed ID:16509464 )
25. Psychoses, Substance-Induced ( PubMed ID:20433105 )
26. Pulmonary Edema ( PubMed ID:12394880 )
27. Respiratory Insufficiency ( PubMed ID:12394880 )
28. Rhabdomyolysis ( PubMed ID:10764196 )
29. Sprains and Strains ( PubMed ID:11740307 )
30. Vomiting ( PubMed ID:10075534 )

Potential Health Benefits For:

1. Dyskinesia, Drug-Induced ( PubMed ID:18762218 )
2. Huntington Disease ( PubMed ID:19476553 )
3. Muscular Atrophy ( PubMed ID:17053101 )
4. Muscular Diseases ( PubMed ID:17111002 )
5. Parkinsonian Disorders ( PubMed ID:19476553 )
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