Beta Testing

Methylparaben

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Potential Risk IndexTM:


About:

Functions :
1. Antimicrobial Preservative – Actively kills and inhibits the growth of unwanted microorganisms which may be harmful.
2. Preservative – Prevents and inhibits the growth of unwanted microorganisms which may be harmful

Methylparaben is an anti-fungal agent often used in a variety of cosmetics and personal-care products. It is also used as a food preservative and has the E number E218. It is approved to use as food and cosmetics preservative in EU. In US, it is generally recognized as safe food substance. [1]

Recent Findings :
Has proven to have high retention rates in the human body and in marine animals, which may lead to eventual toxicity. Can be detected in human breast tissue with breast cancer since it is able to "act like a very weak estrogen in the body" [2] [3]

Some reports also indicate that methylparaben is not carcinogenic when injected, but only when it binds to the human estrogen receptor. In the same study, the potency of methylparaben is "1000x less" when compared to natural estradiol. Since the toxicity of methylparaben is predominantly based on its binding to the human estrogen receptor, it makes the toxicity of methylparaben, controversial. [6] [7]

Scientific References :
1. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/7456

2. Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. (J Appl Toxicol. 2008 Jul;28(5):561-78. DOI: 10.1002/jat.1358.)

3. Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum. (J Appl Toxicol. 2012 Mar;32(3):219-32. DOI: 10.1002/jat.1786. Epub 2012 Jan 12.)

4. Methylparaben stimulates tumor initiating cells in ER+ breast cancer models. (J Appl Toxicol. 2017 Apr;37(4):417-425. DOI: 10.1002/jat.3374. Epub 2016 Sep 1.)

5. Elevated Accumulation of Parabens and their Metabolites in Marine Mammals from the United States Coastal Waters (Environ. Sci. Technol., 2015, 49 (20), pp 12071–12079 DOI: 10.1021/acs.est.5b03601)

6. Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben,

7. Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products (Int J Toxicol. 2008;27 Suppl 4:1-82. DOI: 10.1080/10915810802548359)

8. Evaluation of the health aspects of methyl paraben: a review of the published literature (Food Chem Toxicol. 2002 Oct;40(10):1335-73.)

Regulatory References :
1. EU Scientific Committee on Consumer Safety
http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_019.pdf

2. EU CosIng Annex V, PRESERVATIVES ALLOWED IN COSMETIC PRODUCTS [2017]
– Ref: V/12

3. US FDA Food Additives Status List [2018]

4. EU Approved Food Additive [2018]
– E218

5. US FDA Generally Recognized As Safe (GRAS) Food Substances [2017]


Safety and Hazards (UN GHS):

1. Harmful if swallowed (H302)
2. Causes skin irritation (H315)
3. Causes serious eye damage (H318)
4. Causes serious eye irritation (H319)
5. May cause respiratory irritation (H335)
6. Harmful to aquatic life (H402)
7. Harmful to aquatic life with long lasting effects (H412)

Potential Health Concerns For:

1. Abnormalities, Multiple ( PubMed ID:23637088 )
2. Birth Weight ( PubMed ID:25061923 )
3. Dermatitis, Allergic Contact ( PubMed ID:26795242 )
4. Digestive System Abnormalities ( PubMed ID:23637088 )
6. Eye Abnormalities ( PubMed ID:23637088 )
7. Infertility, Female ( PubMed ID:27286252 )
8. Prenatal Injuries ( PubMed ID:23637088 )

Potential Health Benefits For:

1. Cognition Disorders ( PubMed ID:23068419 )
2. Neurotoxicity Syndromes ( PubMed ID:23068419 )
3. Psychomotor Agitation ( PubMed ID:23068419 )
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