Beta Testing

Tocopherol; Alpha-Tocopherol

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Potential Risk IndexTM:


About:

Functions :
1. Antioxidant – Reduces oxidation to prevent the formation of free radicals which may be harmful to health
2. Dietary / Nutritional Supplement – Vitamins, minerals, proteins, fatty acids or probiotics which is eaten to improve nutritional intake

Alpha-Tocopherol is the form of vitamin E that is preferentially absorbed and accumulated in human. The main source found in supplements and in the European diet, where the main dietary sources are olive and sunflower oils. Alpha tocopherol and other vitamin E substances are antioxidants, which means they can help the body fight off a range of degenerative conditions. Vitamin E is beneficial to overall body function, and a regular part of a healthy diet. When used as food additive, alpha-tocopherol has a E number 307.

In cosmetics and personal care products, Tocopherol and other ingredients made from Tocopherol, including Tocopherol esters are used in the formulation of lipstick, eye shadow, blushers, face powders and foundations, moisturizers, skin care products, bath soaps and detergents, hair conditioners, and many other products.

It is approved to use as food additive in EU and generally recognized as safe food substance in US.

Scientific References :
1. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/2117

Regulatory References :
1. EU Approved Food Additive [2018]

2. US FDA Food Additives Status List [2018]

3. US FDA Generally Recognized As Safe (GRAS) Food Substances [2017]


Safety and Hazards (UN GHS):

1. May cause long lasting harmful effects to aquatic life (H413)

Potential Health Concerns For:

1. Abdominal Pain ( PubMed ID:16260695 )
2. Abnormalities, Multiple ( PubMed ID:24657723 )
3. Asthenia ( PubMed ID:16260695 )
4. Central Nervous System Diseases ( PubMed ID:18942769 )
5. Diabetes Mellitus, Type 2 ( PubMed ID:16506275 )
6. Gastrointestinal Diseases ( PubMed ID:9199886 )
7. Headache ( PubMed ID:16260695 )
9. Tobacco Use Disorder ( PubMed ID:9269585 )
10. Vertigo ( PubMed ID:16260695 )

Potential Health Benefits For:

1. Acute Kidney Injury ( PubMed ID:19766176 )
2. Anemia, Sickle Cell ( PubMed ID:15997260 )
3. Ataxia with vitamin E deficiency ( PubMed ID:10896705 )
5. Body Weight Changes ( PubMed ID:23633841 )
6. Brain Injuries ( PubMed ID:14645467 )
7. Carcinoma 256, Walker ( PubMed ID:19781538 )
8. Cardiovascular Diseases ( PubMed ID:19769483 )
9. Cell Transformation, Neoplastic ( PubMed ID:21344382 )
10. Chemical and Drug Induced Liver Injury ( PubMed ID:20803752 )
11. Chromosome Breakage ( PubMed ID:26332274 )
12. Cognition Disorders ( PubMed ID:19464315 )
13. Cystitis ( PubMed ID:15232716 )
14. Disease Progression ( PubMed ID:23859036 )
15. Drug-Related Side Effects and Adverse Reactions ( PubMed ID:7616398 )
16. Esophagitis, Peptic ( PubMed ID:18547560 )
18. Fibrosis ( PubMed ID:16260695 )
20. Glomerulosclerosis, Focal Segmental ( PubMed ID:7838258 )
21. Hemolysis ( PubMed ID:10704919 )
22. Hyperkinesis ( PubMed ID:28065758 )
23. Hyperlipidemias ( PubMed ID:7838258 )
24. Hyperplasia ( PubMed ID:23633841 )
25. Hypertension ( PubMed ID:9880131 )
26. Hypoglycemia ( PubMed ID:17429802 )
27. Hypopigmentation ( PubMed ID:28065758 )
28. Ischemia ( PubMed ID:8891671 )
29. Kidney Diseases ( PubMed ID:18502357 )
30. Leukemia, Promyelocytic, Acute ( PubMed ID:21869839 )
31. Liver Neoplasms ( PubMed ID:7852184 )
32. Lung Neoplasms ( PubMed ID:16401635 )
33. Memory Disorders ( PubMed ID:15364477 )
34. Muscular Diseases ( PubMed ID:1566986 )
35. Musculoskeletal Abnormalities ( PubMed ID:28065758 )
36. Myocardial Infarction ( PubMed ID:16757080 )
37. Necrosis ( PubMed ID:19066852 )
38. Neoplasm Metastasis ( PubMed ID:19781538 )
39. Neoplasms, Experimental ( PubMed ID:21869839 )
40. Nerve Degeneration ( PubMed ID:1806894 )
41. Nervous System Diseases ( PubMed ID:11752462 )
42. Neural Tube Defects ( PubMed ID:12739027 )
43. Oligospermia ( PubMed ID:27823922 )
44. Osteolysis ( PubMed ID:19781538 )
45. Ovarian Diseases ( PubMed ID:23633841 )
47. Pericardial Effusion ( PubMed ID:30823661 )
48. Poisoning ( PubMed ID:16614824 )
49. Precancerous Conditions ( PubMed ID:9093712 )
50. Proteinuria ( PubMed ID:14714169 )
51. Pseudoxanthoma Elasticum ( PubMed ID:17845175 )
52. Pulmonary Eosinophilia ( PubMed ID:14606601 )
53. Radiation Injuries ( PubMed ID:16260695 )
54. Renal Insufficiency ( PubMed ID:11700016 )
55. Reperfusion Injury ( PubMed ID:12910483 )
56. Respiratory Hypersensitivity ( PubMed ID:24333275 )
57. Retinitis Pigmentosa ( PubMed ID:16849425 )
58. Seizures ( PubMed ID:17543232 )
59. Testicular Diseases ( PubMed ID:27823922 )
60. Uterine Diseases ( PubMed ID:23633841 )
61. Weight Gain ( PubMed ID:30057697 )
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